- Al Pacino as Lt. Vincent Hanna (in negotiations) - Robert DeNiro as Neil McCauley (in negotiations) - Val Kilmer as Chris Shiherlis (in negotiations)
- Adam Sandler as Various / ... (45 episodes, 1990-2002) - Alec Baldwin as Himself - Host / ... (16 episodes, 1990-2006) - Beck as Musical Guest (5 episodes, 1997-2005) - Ben Affleck as Host / ... (5 episodes, 1999-2004) - Ben Stiller as Various / ... (7 episodes, 1987-2000) - Beyonce Knowles as Herself / ... (4 episodes, 2001-2004) - Bill Murray as Various / ... (78 episodes, 1977-1999) - Billy Corgan as Musical Guest (4 episodes, 1993-2003) - Billy Crystal as Various / ... (21 episodes, 1976-1985) - Bonnie Raitt as Musical Guest (4 episodes, 1978-1994) - Britney Spears as Musical Guest / ... (4 episodes, 2000-2003) - Candice Bergen as Host (5 episodes, 1975-1990) - Cheri Oteri as Various (99 episodes, 1995-2000) - Chevy Chase as Various / ... (46 episodes, 1975-2001) - Chris Farley as Various / ... (102 episodes, 1990-1997) - Chris Kattan as Various / ... (150 episodes, 1996-2006) - Chris Rock as Various / ... (63 episodes, 1990-1998) - Christian Slater as Host / ... (3 episodes, 1991-1994) - Christina Ricci as Host / ... (3 episodes, 1991-1999) - Christopher Reeve as Himself / ... (3 episodes, 1981-1985) - Christopher Walken as Host / ... (6 episodes, 1990-2003) - Dan Aykroyd as Various / ... (94 episodes, 1975-2003) - Danny DeVito as Host / ... (9 episodes, 1980-1999) - David Bowie as Musical Guest / ... (4 episodes, 1979-1999) - David Spade as Various / ... (126 episodes, 1990-2005) - Dennis Miller as Various (111 episodes, 1985-1991) - Drew Barrymore as Host / ... (7 episodes, 1982-2006) - Eddie Murphy as Various / ... (65 episodes, 1980-1984) - Elvis Costello as Muscial Guest / ... (3 episodes, 1977-1991) - Eminem as Musical Guest (4 episodes, 1999-2004) - Eric Idle as Himself - Host / ... (6 episodes, 1976-1986) - Garth Brooks as Host / ... (3 episodes, 1992-1999) - Gwen Stefani as Herself - Musical Guest / ... (4 episodes, 1996-2005) - Gwyneth Paltrow as Herself / ... (4 episodes, 1999-2001) - Jack Black as Himself - Host / ... (4 episodes, 1998-2005) - James Belushi as Various / ... (36 episodes, 1983-2003) - Janeane Garofalo as Various (14 episodes, 1994-1995) - Jay Mohr as Various (39 episodes, 1993-1995) - Jennifer Aniston as Herself - Host / ... (3 episodes, 1995-2004) - Jerry Seinfeld as Host / ... (3 episodes, 1992-2006) - Jon Bon Jovi as Musical Guest / ... (3 episodes, 1993-2001) - Justin Timberlake as Himself / ... (4 episodes, 2000-2005) - Kirsten Dunst as George Bush's Granddaughter / ... (3 episodes, 1988-2002) - Lenny Kravitz as Musical Guest / ... (3 episodes, 1993-2002) - Lindsay Lohan as Host / ... (4 episodes, 2004-2006) - Madonna as Herself / ... (5 episodes, 1985-1993) - Mariah Carey as Herself (3 episodes, 1990-1997) - Martin Short as Various / ... (21 episodes, 1984-2005) - Mick Jagger as Musical Guest / ... (5 episodes, 1978-2001) - Mike Myers as Various / ... (126 episodes, 1989-2005) - Neil Young as Musical Guest / ... (4 episodes, 1989-2005) - Paul McCartney as Guest / ... (3 episodes, 1980-1993) - Prince as Musical Guest / ... (3 episodes, 1981-2006) - Robert DeNiro as Himself / ... (5 episodes, 1992-2004) - Robin Williams as Himself - Host / ... (4 episodes, 1981-1988) - Sarah Michelle Gellar as Host / ... (5 episodes, 1998-2002) - Sheryl Crow as Herself - Musical Guest / ... (3 episodes, 1996-2005) - Steve Martin as Himself - Host / ... (22 episodes, 1976-2006) - Sting as Musical Guest / ... (6 episodes, 1987-1999) - Tina Turner as Musical Guest / ... (3 episodes, 1981-1997) - Will Ferrell as Various / ... (142 episodes, 1995-2005)
