- Calista Flockhart as Christine Taylor (segments "Goodnight Lilly, Goodnight Christine" and "This is Dr. Keener") - Cameron Diaz as Carol Faber (segment "Love Waits For Kathy") - Glenn Close as Dr. Elaine Keener (segments "This is Dr. Keener" and "Fantasies about Rebecca") - Holly Hunter as Rebecca (segment "Fantasies About Rebecca") - Valeria Golino as Lilly (segment "Goodnight Lilly, Goodnight Christine")
